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Comparison of reference values for immune recovery between event-free patients receiving haploidentical

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《医学前沿（英文）》 2018年第12卷第2期页码 153-163 doi: 10.1007/s11684-017-0548-1

摘要：

To establish optimal reference values for recovered immune cell subsets, we prospectively investigated post-transplant immune reconstitution (IR) in 144 patients who received allogeneic stem cell transplantation (allo-SCT) and without showing any of the following events: poor graft function, grades II?IV acute graft-versus-host disease (GVHD), serious chronic GVHD, serious bacterial infection, invasive fungal infection, or relapse or death in the first year after transplantation. IR was rapid in monocytes, intermediate in lymphocytes, CD3⁺ T cells, CD8⁺ T cells, and CD19⁺ B cells, and very slow in CD4⁺ T cells in the entire patient cohort. Immune recovery was generally faster under HLA-matched sibling donor transplantation than under haploidentical transplantation. Results suggest that patients with an IR comparable to the reference values display superior survival, and the levels of recovery in immune cells need not reach those in healthy donor in the first year after transplantation. We suggest that data from this recipient cohort should be used as reference values for post-transplant immune cell counts in patients receiving HSCT.

关键词： immune reconstitution hematopoietic stem cell transplantation event-free patients reference range

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Free radical scavenging window of infertile patients with polycystic ovary syndrome: correlation with

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《医学前沿（英文）》 2017年第11卷第2期页码 247-252 doi: 10.1007/s11684-017-0519-6

摘要：

The activity of free radicals in follicular fluid was related to ovarian responsiveness, in vitro fertilization (IVF), and embryo transfer success rate. However, studies analyzing the relationship between the free radical scavenging capacity and embryo quality of infertile women with polycystic ovarian syndrome (PCOS) were lacking. The aim of this study was to evaluate the relationship between the free radical scavenging window of women with PCOS and their embryo quality. The free radical scavenging capacity of follicular fluid from women with PCOS was determined by a,a-diphenyl-b-picrylhydrazyl (DPPH), 2,2-azinobis (3-ethylbenzthiazoline-6-sulphonic acid) assay, superoxide radical, and reactive oxygen species (ROS) assay. In the DPPH and ROS assays, the follicular fluid from grades I and II embryos was significantly higher than the follicular fluid from grades III and IV embryos. The lower control limit of DPPH radical scavenging capacity and upper control limit of ROS level were 13.2% and 109.0 cps, respectively. The calculated lower control limit and upper control limit were further confirmed in the follicular fluid of embryos of all grades. These cut-off values of free radical scavenging activity of follicular fluid could assist embryologists in choosing the development of embryos in PCOS patients undergoing IVF.

关键词： in vitro fertilization PCOS free radical embryo quality

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Identification of surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potential

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《医学前沿（英文）》 2018年第12卷第2期页码 189-195 doi: 10.1007/s11684-017-0533-8

摘要：

Obstructive sleep apnea syndrome (OSAS) increases the risk of post-surgery complications. This study uses Berlin Questionnaire (BQ) to identify Chinese adult surgical patients who are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverse respiratory events in the post anesthesia care unit (PACU). Results indicated that only 11.4% of the patients were considered at a high risk of OSAS. Age and body mass index are the key factors for the risk of OSAS prevalence in China and also gender specific. Furthermore, the incidence of adverse respiratory events in the PACU was higher in patients with high risk of OSAS than others (6.8% vs. 0.9%, <0.001). They also stayed longer than others in the PACU (95±28 min vs. 62±19 min, <0.001). Age, high risk for OSAS, and smoking were independent risk factors for the occurrence of adverse respiratory events in the PACU. The BQ may be adopted as a screening tool for anesthesiologists in China to identify patients who are at high risk of OSAS and determine the potential risk of developing postoperative respiratory complications in the PACU.

关键词： obstructive sleep apnea Berlin Questionnaire Chinese surgical patients adverse respiratory event

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BUEES: a bottom-up event extraction system

Xiao DING,Bing QIN,Ting LIU

《信息与电子工程前沿（英文）》 2015年第16卷第7期页码 541-552 doi: 10.1631/FITEE.1400405

摘要： Traditional event extraction systems focus mainly on event type identification and event participant extraction based on pre-specified event type paradigms and manually annotated corpora. However, different domains have different event type paradigms. When transferring to a new domain, we have to build a new event type paradigm and annotate a new corpus from scratch. This kind of conventional event extraction system requires massive human effort, and hence prevents event extraction from being widely applicable. In this paper, we present BUEES, a bottom-up event extraction system, which extracts events from the web in a completely unsupervised way. The system automatically builds an event type paradigm in the input corpus, and then proceeds to extract a large number of instance patterns of these events. Subsequently, the system extracts event arguments according to these patterns. By conducting a series of experiments, we demonstrate the good performance of BUEES and compare it to a state-of-the-art Chinese event extraction system, i.e., a supervised event extraction system. Experimental results show that BUEES performs comparably (5% higher -measure in event type identification and 3% higher -measure in event argument extraction), but without any human effort.

关键词： Event extraction Unsupervised learning Bottom-up

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A systematic approach to ON-OFF event detection and clustering analysis of non-intrusive appliance load

Chuan Choong YANG,Chit Siang SOH,Vooi Voon YAP

《能源前沿（英文）》 2015年第9卷第2期页码 231-237 doi: 10.1007/s11708-015-0358-6

摘要： The aim of non-intrusive appliance load monitoring (NIALM) is to disaggregate the energy consumption of individual electrical appliances from total power consumption utilizing non-intrusive methods. In this paper, a systematic approach to ON-OFF event detection and clustering analysis for NIALM were presented. From the aggregate power consumption data set, the data are passed through median filtering to reduce noise and prepared for the event detection algorithm. The event detection algorithm is to determine the switching of ON and OFF status of electrical appliances. The goodness-of-fit (GOF) methodology is the event detection algorithm implemented. After event detection, the events detected were paired into ON-OFF pairing appliances. The results from the ON-OFF pairing algorithm were further clustered in groups utilizing the -means clustering analysis. The -means clustering were implemented as an unsupervised learning methodology for the clustering analysis. The novelty of this paper is the determination of the time duration an electrical appliance is turned ON through combination of event detection, ON-OFF pairing and -means clustering. The results of the algorithm implementation were discussed and ideas on future work were also proposed.

关键词： non-intrusive appliance load monitoring event detection goodness-of-fit (GOF) K-means clustering ON-OFF pairing

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Discrete-event stochastic systems with correlated inputs: Modeling and performance evaluation

《工程管理前沿（英文）》 2022年第9卷第2期页码 214-220 doi: 10.1007/s42524-022-0192-6

摘要： In the majority of the previous works on discrete-event stochastic systems, they have been assumed to have independent input processes. However, in many applications, these input processes can be highly correlated. Furthermore, the performance measures of the systems with correlated inputs can be significantly different from those with independent inputs. In this paper, we provide an overview on some commonly used methods for modeling correlated input processes, and we discuss the difficulties and possible future research topics in the study of discrete-event stochastic systems with correlated inputs.

关键词： discrete-event stochastic system correlated input performance evaluation

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Dynamic behavior of stormwater quality parameters in South Texas

Xubin PAN, Jingyi ZHANG, Wei-Ta FANG, Kim D. JONES

《环境科学与工程前沿（英文）》 2012年第6卷第6期页码 825-830 doi: 10.1007/s11783-012-0465-0

摘要： To control water impairment in urban stormwater, it is important to evaluate changing patterns of water quality parameters in stormwater runoff. Thus, the authors performed a series of experiments to investigate the dynamics of common water parameters during storm events in semi-arid areas, with multiple samples collected and analyzed in field stormwater applications. At this field monitoring site within McAuliffe Park, McAllen, Texas, in the United States, a storm event increased the concentrations of ( ), but this event represented a decreasing trend over the entire event period. Besides, peak intensity of different pollutants in the stormwater runoff occurred at different times other than at any peak flows, representing a complexity of the temporal and spatial measurements. Multi-sample per-event approaches recommended based on the complexity of the hydrograph and different peak intensity times of pollutants. In addition, high bacteria and total suspended solids (TSS) concentrations in the initial stage of the storm event should be considered when designing Best Management Practices (BMPs) and Low Impact Developments (LIDs). New strategies and solutions for addressing ecohydrological challenges should be proposed to avoid collateral damages to their both common wealth in ecosystems and human well-beings.

关键词： event mean concentration first flush multi-sample per event ecohydrology

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Cell-free systems in the new age of synthetic biology

Fernando Villarreal,Cheemeng Tan

《化学科学与工程前沿（英文）》 2017年第11卷第1期页码 58-65 doi: 10.1007/s11705-017-1610-x

摘要： The advent of synthetic biology has ushered in new applications of cell-free transcription-translation systems. These cell-free systems are reconstituted using cellular proteins, and are amenable to modular control of their composition. Here, we discuss the historical advancement of cell-free systems, as well as their new applications in the rapid design of synthetic genetic circuits and components, directed evolution of biomolecules, diagnosis of infectious diseases, and synthesis of vaccines. Finally, we present our vision on the future direction of cell-free synthetic biology.

关键词： cell-free system application

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Clean air captures attention whereas pollution distracts: evidence from brain activities

《环境科学与工程前沿（英文）》 2023年第18卷第4期 doi: 10.1007/s11783-024-1801-x

摘要：

● We find air pollution distracts attention and reveal the neurocognitive mechanisms.

关键词： Air pollution Attention Disengagement Performance Event-related potential

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A comprehensive information database (CID) of breast cancer patients in China

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《医学前沿（英文）》 2012年第6卷第2期页码 212-216 doi: 10.1007/s11684-012-0185-7

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Reliability of foam posturography in assessment of postural balance in the patients with vertigo

LIU Bo, KONG Weijia

《医学前沿（英文）》 2008年第2卷第4期页码 361-365 doi: 10.1007/s11684-008-0069-z

摘要： The postural balance is a important aspect of assessment in vestibular rehabilitation therapy. As the computerized dynamic posturography, the foam posturography performed by using foam in posturography is a useful measurement tool for postural balance. Then, the reliability of foam posturography is critical in clinic. To our knowledge, there is no report about the test-retest reliability of foam posturography in the patients with vertigo in China. The foam posturography was taken on the patients with vertigo in stable state and repeated in 3 to 5 days. In the two assessments of test and retest, all subjects stood under 4 sensory conditions, such as firm surface with eyes open (T1), firm surface with eyes closed (T2), foam surface with eyes open (T3) and foam surface with eyes closed (T4) for 30 seconds respectively. The average sway velocity (SV) of center of pressure (COP) under feet of upright standing was recorded as research parameter. The results of patients with vertigo were compared with those of normal subjects. It demonstrated that all normal subjects did not fall in the two assessments. There were 10 of 34 patients with vertigo at least fell one time during the two assessments, and the SVs of these subjects did not taken the analysis of test-retest reliability. The results showed that: (1) The interclass correlation coefficients (ICC) of all 49 subjects including normal subjects and patients without falling were 0.887–0.973 according to the T1–T4 between two assessment. (2) The SVs between the normal subjects and patients were significantly different in the T2 ( = 2.018, = 0.049) and T4 ( = 3.905, < 0.001) in the first assessment and in the T4 ( = 3.715, = 0.001) in the second. And (3) the cases of falling between two assessments were not significant different ( = 0.073, = 0.787) in the patients with vertigo. It is concluded from this study that the foam posturography has high test-retest reliability to assess the postural balance in the patients with vertigo in stable state, indicating the foam posturography can be used as the valid means to assess the improvement of postural balance for patients with vertigo in the vestibular rehabilitation therapy.

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Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essential

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《医学前沿（英文）》 2016年第10卷第4期页码 437-443 doi: 10.1007/s11684-016-0472-9

摘要：

A phase II study (A2202) was performed to evaluate the efficacy and safety of JAK inhibitor ruxolitinib in 63 Chinese MF patients. Ruxolitinib was given twice a day (bid) at a starting dose of 15 mg (n=25) or 20 mg (n=38) based on a baseline platelet count. About 94.7% of the patients achieved a reduction in spleen size, 27.0% of which exhibited significant reduction (≥35%) at week 24. Significant improvement in debilitating constitutional symptoms, as assessed by MFSAF v2.0, was observed in patients treated with ruxolitinib. Ruxolitinib treatment was generally well tolerated by Chinese patients. Although the treatment was associated with an increase in certain adverse events (AEs) that were established as identified risks (anemia and thrombocytopenia), these AEs were considered manageable in this clinical setting. Ruxolitinib provided substantial reductions in splenomegaly and improvements in symptoms, and was well-tolerated by Chinese patients with MF.

关键词： JAK ruxolitinib Chinese patients myelofibrosis

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Translating the power of TCM into patients’ hope

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《医学前沿（英文）》 2014年第8卷第3期页码 265-267 doi: 10.1007/s11684-014-0329-z

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Hypertension in patients with CKD in China: clinical characteristics and management

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《医学前沿（英文）》 2017年第11卷第3期页码 307-309 doi: 10.1007/s11684-017-0578-8

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AED-Net——异常事件检测网络 Article

王田, 苗子琛, 陈禹昕, 周毅, 单光存, Hichem Snoussi

《工程（英文）》 2019年第5卷第5期页码 930-939 doi: 10.1016/j.eng.2019.02.008

摘要：

长期以来，在拥挤场景中检测异常事件都是一项具有挑战性的任务。为解决这一问题，本文提出了一种名叫异常事件检测网络（AED-Net）的自监督框架，它由主成分分析网络（PCANet）和核主成分分析（kPCA）组成。该框架以不同场景的监控视频序列为原始数据，通过训练PCANet以提取人群情况的高级语义。kPCA可作为一种单类分类器，被用于识别场景中的异常事件。与目前流行的一些深度学习方法相比，该框架完全是自监督的，因为它只使用正常情况下的视频序列。通过对明尼苏达大学公共监测人类活动数据集（UMN数据集）和加州大学圣地亚哥分校监测异常数据集（UCSD数据集）进行全局和局部异常事件进行检测发现，与其他最先进的方法相比，该方法具有更好的等误差率（EER）和曲线下面积（AUC）。此外，通过增加局部响应归一化（LRN）层，我们对原有的AED-Net进行了改进。结果表明，该改进版在提高框架的泛化能力方面表现出更好的性能。

关键词：异常事件检测异常事件检测网络主成分分析网络核主成分分析